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KMID : 0376219790160010087
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Chonnam Medical Journal
1979 Volume.16 No. 1 p.87 ~ p.92
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Inhibitory Effect of the Cervical Sympathetics on Submaxillary Secretion in the Cat
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Abstract
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It is known that the submaxillary secretion elicited by chorda stimulation can be reduced by the superimposed excitation of the cervical sympathetics. However, the inhibitory mechanism of the sympathetics is far from settled. To clarify the mechanism, inhibitory effect of the nerve on the submaxillary secretion was investigated in urethane-anesthetized cats. The results obtained were as follows
1. Stimulation of the chorda tympani or pilocarpine infusion elicited copious salivary secretion and, simultaneously, increased the blood flow through the submaxillary gland.
2. Salivary secretion and increased blood flow evoked by chorda stimulation or pilocarpine infusion were both decreased either by the superimposed cervical sympathetic stimulation or by norepinephrine injection. And the effects of sympathetic stimulation or norepinephrine were abolished in the presence of phenoxybenzamine.
3. Salivary secretion and increased blood flow evoked by chorda stimulation were both decreased during vagal stimulation.
4. Salivary secretion and increased blood flow evoked by chorda stimulation were both decreased by clamping the common carotid artery.
These results suggest that inhibitory effect of the cervical sympathetic is closely related to decreased blood flow, and that the decrement of blood flow by the sympathetics is mediated by the adrenergic alpha-receptors in the blood vessels of the gland.
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